![]() Over aa 434‑531, human PKM2 shares 95% aa sequence identity with mouse PKM2.ĬTHBP, Cytosolic thyroid hormone-binding protein, MGC3932, OIP-3, OIP3, OIP3EC 2.7.1. There are additional isoform variants of PKM2 that show either a deletion of aa 59‑132, or a 67 aa substitution for aa 1‑82. Formerly known as Scarecrow Boat, Nothing Rhymes With Blorange, Just The Tip, The Andy Andy Andies, etc. This variant shows limited expression (striated muscle) and hyperbolic Michaelis-Menten kinetics. Get news from your favorite band from Pawnee, Indiana and NBCs Parks and Recreation, Mouse Rat. PKM1 is another PKM gene splice variant that shows a 45 aa substitution forĪa 389‑433 of PKM2. It contains a catalytic region (aa 43‑527) plus four utilized Ser/Thr and Tyr phosphorylation sites, respectively. Human PKM2 is 531 amino acids (aa) in length. PKM2 is known to be regulated by the binding of T3 and Fru-1,6-bisP. Notably, in tumor cells, select oncogenes appear to induce PKM2 homodimerization which limits PKM2 activity. PKM2 exists as a marginally active monomer, with full activity achieved through homotetramerization. Thus, when active, PKM2 promotes energy production and glycolysis. Mouse Costume Accessory Set - Grey and Pink Ears Headband, Bow Tie and Tail Accessories Set for Rat Costume for Toddlers and Kids 4.0 out of 5 stars 390 14.99 14. ![]() ![]() PKM2 generates ATP and pyruvate by catalyzing the transfer of a phosphoryl group from PEP to ADP. It is widely expressed, being found both intracellularly and in blood, and represents the more common splice variant of the PKM gene. PKM2 (Pyruvate Kinase isoenzyme M2 also p58, OIP3, THBP1 and CTHBP) is a 58-60 kDa member of the PK family of enzymes. ![]()
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